Biochem/physiol Actions

Reversible: yes

Product does not compete with ATP.

Primary TargetPPARγ

kd = ~ 8 µM as PPARγ antagonist

Cell permeable: yes

General description

A cell-permeable dipeptide that acts as a selective and reversible PPARγ antagonist (K_D ~8 µM). Shown to inhibit the agonist activity of Rosiglitazone (100 nM) in a dose-dependent manner (IC₅₀ = 31.9 µM) in transfected COS-7 cells.

A cell-permeable dipeptide that acts as a selective and reversible PPARγ antagonist (K_D = ~ 8 µM). Shown to inhibit the agonist activity of Rosiglitazone (100 nM) in a dose-dependent manner (IC₅₀ = 31.9 µM) in transfected COS-7 cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Ye, F., et al. 2006. Chembiochem7, 74.

Packaging

Packaged under inert gas

50 mg in Plastic ampoule

Preparation Note

Addition of a small amount of acid or base may be required for complete solubilization.

Reconstitution

Following reconstitution aliquot freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)